- 3 March
- 4 March
Copa Sudamericana Betting Lines
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- Cobresal-Audax Italiano
- Deportivo Cuenca-Libertad Loja
- Sportivo Trinidense-Club Olimpia
- Caracas-Metropolitanos
- Independiente Petrolero-Guabira
- Alianza Atletico Sullana-Deportivo Garcilaso
- Academia Puerto Cabello-Monagas
- Universidad de Chile-Palestino
- Club Nacional Asuncion-Deportivo Recoleta
- Montevideo City Torque-Defensor Sporting
- Club Atletico Nacional SA-Millonarios
- Orense Sporting Club-Club Social y Deportivo Macara
- Club Atletico Boston River-Racing Club de Montevideo
- Club Cienciano Cusco-Melgar
- Club Blooming-San Antonio Bulo Bulo